Many GWAS studies and related studies have detected genetic factors may be associated with SCZ, which indicates a genetic background of schizophrenia [2-4]. One of these genes is the VMAT2 gene, which is located at 10q25. A suspected locus of schizophrenia detected by a systematic genome wide linkage study had a LOD score of 3.87 [5]. VMAT2 is an integral membrane protein that transports monoamine from the cytoplasm to the vesicles [6]. VMAT2 protein mainly expresses in the brain and plays an important role in the transmission of monoamineC:UsersAdministratorAppDataLocalYodaoDeskDictframe20140816171600javascript:void(0); including dopamine